임상 실험
한 화합물이 전임상 연구에서 상당한 전망을 보이면, 인간 환자에서의 안전성과 유효성을 평가하기 위해 임상 실험에 들어갈 수 있습니다.임상 실험은 엄격한 테스트를 통해 암 치료로서의 해당 화합물의 유효성을 보장하기 위해 여러 단계를 포함합니다.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
임상 실험의 학술 논문
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
화학 물질
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors
화학 물질
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(1RS)-2-(4''-methoxy-4'-phenoxybenzenesulfonyl)-1,2,3,4-tetrahydro-norarmano-1-carboxylic acid
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Optimization of the anti-cancer activity of the phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: Switching thiourea with 1,2,3-triazole
화학 물질
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(1-(5-chloro-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)(phenyl)methanone
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Synthesis and biological evaluation of the pyrazole class of cyclooxygenase-2-inhibitors
화학 물질
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3-(4-chlorophenyl)-1-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde
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Pyridine analogues of nimesulide: Design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors
화학 물질
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4-nitro-3-(3-bromophenylamino)pyridine N-oxide
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Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes
화학 물질
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3-{4-[2-amino-6-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidin-4-yloxy]phenyl}-2-methyl-2-phenoxypropionic acid
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Synthesis of macrocyclic, potential inhibitors using a generic scaffold
화학 물질
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2-benzyloxycarbonylamino-3-iodo-propionic acid tert-butyl ester
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Design and synthesis of new transition-state analogue inhibitors of aspartate transcarbamylase
화학 물질
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dibenzyl N-(phosphonoacetyl)aspartate
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Synthesis and evaluation of α-thymidine analogues as novel antimalarials
화학 물질
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5'-deoxy-5'-(4-nitrobenzamido)thymidine
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Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action
화학 물질
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1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate
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Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
화학 물질
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6-{2-[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetylamino}hexanoic acid
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SYNTHESIS AND STUDY OF THE ANTIVIRAL ACTIVITY OF PROPANOLAMINE DERIVATIVES
화학 물질
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Benzamide, N-(2-hydroxy-3-phenoxypropyl)-4-nitro-
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Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties
화학 물질
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methyl 3-(4-((2-chloropyridin-4-yl)ethynyl)phenyl)propanoate
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Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs
화학 물질
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3-Heptanone, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
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Synthesis and Biological Activity of the Four Stereoisomers of 6-<4-<3-<<2-Hydroxy-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>propyl>amino>propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a Combined Vasodilator and β-Adrenoceptor Antagonist
화학 물질
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2-Propanol, 1-amino-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (S)-
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Silica gel
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Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT(1A) receptor antagonists
화학 물질
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2-[4-(4-Ethoxy-phenyl)-butyl]-isoindole-1,3-dione
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Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ2 receptors
화학 물질
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2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one
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Preparation of phosphonooxymethyl prodrugs of HIV-1 attachment inhibitors
화학 물질
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{3-[(4-benzoylpiperazin-1-yl)(oxo)acetyl]-4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate
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New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
화학 물질
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6-[(4-Chloro-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one
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Novel benzofuran derivatives for PET imaging of β-amyloid plaques in Alzheimer's disease brains
화학 물질
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2-(4'-nitrophenyl)-5-methoxybenzo[b]furan
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Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
화학 물질
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Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
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Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII
화학 물질
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4-(5-phenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
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아민
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4- 디메틸 아미노 피리딘
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Identification of arginine analogues as antagonists and agonists for the melanocortin-4 receptor
화학 물질
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(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER
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Synthesis and antiviral activity of 5-substituted cytidine analogues: Identification of a potent inhibitor of viral RNA-dependent RNA polymerases
화학 물질
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2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate
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Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M
화학 물질
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1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone
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Development of prohibitin ligands against osteoporosis
화학 물질
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4-isopropylbenzenesulfonyl azide
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Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus (1)
화학 물질
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2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
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Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition
화학 물질
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2-((4-chlorophenyl)disulfanyl)pyridine
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Thiophenol
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중탄산 나트륨
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Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan; CPT-11) toxicity
화학 물질
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N,N'-(1,4-phenylene)bis(2-fluorobenzenesulfonamide)
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피리딘
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Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents
화학 물질
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3-피리다진카보닐 클로라이드, 1,6-디하이드로-6-옥소-(9CI)
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Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
화학 물질
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methyl 3-{N-(1-butyl)-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate
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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
화학 물질
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ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
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A concise synthesis of a novel insulin-like growth factor i receptor (IGF-IR) inhibitor
화학 물질
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N-(2-(3-(벤질옥시)페닐)-2-옥소에틸)아세타미드
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METHANOL
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Phentydrone
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Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones
화학 물질
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5-[4-(3-ethyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
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Development of dimeric modulators for anti-apoptotic Bcl-2 proteins
화학 물질
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C26H24N2O6S4
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Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
화학 물질
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7-methoxy-8-{6-[2-methoxy-4-[(E)-3-morpholino-3-oxo-1-propenyl]phenoxy]hexyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
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Structure-based design of substituted piperidines as a new class of highly efficacious oral direct renin inhibitors
화학 물질
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C10H13ClN2O3
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브롬화 마그네슘
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HCl
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Studies Related to Maytansinoids
화학 물질
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(3R,4R,5R)-3-benzoyloxy-4,5-dihydroxycyclohexanone 4,5-O-cyclohexylidene acetal
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Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease
화학 물질
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5-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)pentyl 4-methylbenzenesulfonate
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