화학 합성
후보 화합물이 선택되면 설계한 잡화 화합물을 만들기 위해 화학적 합성이 수행됩니다.이는 포아사이드 유사체와 질소 갓조분의 결합에 의존하면서 얻은 분자가 원하는 결합 성질을 유지하도록 하는 데 관련될 수 있다.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
화학 합성의 학술 논문
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
화학 물질
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Synthesis and characterization of a fluorescent analogue of methotrexate
화학 물질
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N~2~-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-D-lysine
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Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents
화학 물질
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1-(4-amino-3-n-butoxyphenyl)ethanone
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Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors
화학 물질
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(1RS)-2-(4''-methoxy-4'-phenoxybenzenesulfonyl)-1,2,3,4-tetrahydro-norarmano-1-carboxylic acid
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Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design
화학 물질
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2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
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Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors
화학 물질
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4-fluoro-2-(methoxycarbonylmethyl)benzenesulfonamide
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Pyridine analogues of nimesulide: Design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors
화학 물질
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4-nitro-3-(3-bromophenylamino)pyridine N-oxide
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Design and synthesis of new transition-state analogue inhibitors of aspartate transcarbamylase
화학 물질
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dibenzyl N-(phosphonoacetyl)aspartate
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Design, synthesis, antimycobacterial evaluation, and in silico studies of 3-(phenylcarbamoyl)-pyrazine-2-carboxylic acids
화학 물질
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3-(anilinocarbonyl)-2-pyrazinecarboxylic acid
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Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring
화학 물질
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1-Methyl-5-(5-nitro-2-propoxyphenyl)-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives
화학 물질
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6-(4-methoxybenzylamino)-9-(tetrahydropyran-2-yl)-9H-purine
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Synthesis of new substance P analogues releasing histamine from rat peritoneal mast cells
화학 물질
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Boc-Pro-Lys(Z)-Pro-OCH3
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Synthesis and Evaluation of 1- and 2-Substituted Fentanyl Analogues for Opioid Activity
화학 물질
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Carbamic acid, [2-oxo-2-[(2-phenylethyl)amino]ethyl]-, phenylmethyl ester
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Structure-based design of 5-Methylpyrimidopyridone derivatives as new wild-type sparing inhibitors of the epidermal growth factor receptor triple mutant (EGFRL858R/T790M/C797S)
화학 물질
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tert-butyl (S)-3-((5-bromo-2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate
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bis(benzonitrile)palladium(II) dichloride
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Synthesis and Biological Activity of the Four Stereoisomers of 6-<4-<3-<<2-Hydroxy-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>propyl>amino>propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a Combined Vasodilator and β-Adrenoceptor Antagonist
화학 물질
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2-Propanol, 1-amino-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (S)-
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Silica gel
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Preparation of phosphonooxymethyl prodrugs of HIV-1 attachment inhibitors
화학 물질
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{3-[(4-benzoylpiperazin-1-yl)(oxo)acetyl]-4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate
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Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds
화학 물질
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7-bromo-N-[(1-oxyl-4-bromo-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical
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Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity
화학 물질
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E-3-(5-benzylidene-2-oxo-5,6-dihydro-2H-pyran-3-yl)propionic acid methyl ester
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anisaldehyde
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트리 에틸 아민
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Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor
화학 물질
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Hexanoic acid, 4-oxo-6-[[(phenylmethoxy)carbonyl]amino]-
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Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin
화학 물질
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{(S)-3-Benzyloxy-1-[(2S,6R)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-propoxy}-tert-butyl-diphenyl-silane
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Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
화학 물질
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Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
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Design, synthesis, and evaluation of water-soluble morpholino-decorated paclitaxel prodrugs with remarkably decreased toxicity
화학 물질
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2’-(4-nitrophenoxycarbonyl)paclitaxel
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Synthesis and biological evaluation of orally active matrix metaloproteinase inhibitors
화학 물질
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(2R)-2-bromo-4-methylpentanoic acid t-butyl ester
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Design, synthesis, and activity evaluation of novel N-benzyl deoxynojirimycin derivatives for use as α-glucosidase inhibitors
화학 물질
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2,3-dibromo-1-(bromomethyl)-4,5-dimethoxybenzene
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Studies on the synthesis of nicotinamide nucleoside and nucleotide analogues and their inhibitions towards CD38 nadase
화학 물질
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((3aR,5R,6S,6aS)-6-fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate
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Synthesis and Evaluation of Dolastatin 10 Analogues Containing Heteroatoms on the Amino Acid Side Chains
화학 물질
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1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-, 1,1-dimethylethyl ester, (2S)-
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Design, synthesis, and biological evaluation of novel piperidine-4- carboxamide derivatives as potent CCR5 inhibitors
화학 물질
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tert-butyl 4-(4-cyanobenzylcarbamoyl)piperidine-1-carboxylate
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Synthesis and evaluation of 2′,4′,6′-trihydroxychalcones as a new class of tyrosinase inhibitors
화학 물질
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4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-
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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
화학 물질
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ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
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Systematic synthesis of novel phosphoglycolipid analogues as potential agonists of GPR55
화학 물질
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(((15-bromopentadecyl)oxy)methyl)benzene
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Design, synthesis and biological evaluation of novel thieno[3,2-d] pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents
화학 물질
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2-(4-nitrophenyl)-4-hydroxythieno[3,2-d]pyrimidine
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Synthesis and structure-activity relationships of di- and trisaccharide inhibitors for Shiga-like toxin Type 1
화학 물질
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methyl 2,3,6-tri-O-benzoyl-4-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-β-D-galactopyranoside
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Scaffold hopping strategy toward original pyrazolines as selective CB 2 receptor ligands
화학 물질
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1-(4-chloro-3-methylphenyl)heptan-1-one
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Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C
화학 물질
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Benzeneacetonitrile, a-[bis[4-[2-(diethylamino)ethoxy]phenyl]methylene]-
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Synthesis, pharmacological evaluation and docking studies of coumarin derivatives
화학 물질
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4-methyl-2-oxo-2H-chromen-7-yl N-phenylglycinate
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Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents
화학 물질
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(E)-2-(4-fluorostyryl)-3,4,5-trimethoxybenzaldehyde
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Synthesis of novel indole hydrazone derivatives and evaluation of their antiplatelet aggregation activity
화학 물질
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(2E)-2-(2,2-diphenylethylidene)hydrazinecarboxamide
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Design, synthesis and anticancer activities of hybrids of indole and barbituric acids-Identification of highly promising leads
화학 물질
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C22H19N3O5S
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인돌-3-카복스알데하이드
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Barbituric acid
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Synthesis and characterization of novel azo-morphine derivatives for possible use in abused drugs analysis
화학 물질
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Z-phenyl-2-azo-6-acetyl-morphine
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CODEINE
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Aniline hydrochloride
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Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications
화학 물질
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(2R,3S,4R,5R)-5-((benzoyloxy)methyl)-3-chlorotetrahydrofuran-2,4-diyl dibenzoate
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Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases
화학 물질
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diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate
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Silica gel
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Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor
화학 물질
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1-(cyclohexylmethyl)-4-iodo-1H-pyrazole
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Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers
화학 물질
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1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
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푸마르산
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