체외 시험
그런 다음 암세포주를 사용하여 합성된 화합물을 체외 테스트합니다.연구원들은 그들의 세포 독성, DNA 손상을 유도하는 능력, 그리고 위상 이기종 효소 II와의 상호작용을 평가했습니다. 세포 활력 테스트와 DNA 손상 테스트와 같은 다양한 테스트와 기술은 이들 화합물의 생물학적 활성을 평가하는 데 사용되었습니다.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
체외 시험의 학술 논문
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
화학 물질
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Design of potent and selective antagonists of the vasopressor responses to arginine-vasopressin
화학 물질
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3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
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Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes
화학 물질
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3-{4-[2-amino-6-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidin-4-yloxy]phenyl}-2-methyl-2-phenoxypropionic acid
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A study of anti-inflammatory and analgesic activity of new 2,4,6-trisubstituted pyrimidines
화학 물질
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3-bromo-4'-amino-chalcone
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Design, synthesis, and evaluation of novel anti-trypanosomal compounds
화학 물질
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N-(3-chlorobenzyl)-N-methylpiperidin-4-amine
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Synthesis of new substance P analogues releasing histamine from rat peritoneal mast cells
화학 물질
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Boc-Pro-Lys(Z)-Pro-OCH3
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Structure-based design of 5-Methylpyrimidopyridone derivatives as new wild-type sparing inhibitors of the epidermal growth factor receptor triple mutant (EGFRL858R/T790M/C797S)
화학 물질
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tert-butyl (S)-3-((5-bromo-2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate
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bis(benzonitrile)palladium(II) dichloride
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Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ2 receptors
화학 물질
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2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one
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New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
화학 물질
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6-[(4-Chloro-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one
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Synthesis and evaluation of novel benzimidazole derivatives as antimicrobial agents
화학 물질
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N-(4-chloro-3-fluorophenyl)-2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)acetamide
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Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII
화학 물질
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4-(5-phenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
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아민
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4- 디메틸 아미노 피리딘
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Design, synthesis and antifungal activity of novel fenfuram-diarylamine hybrids
화학 물질
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N-(4-BroMo-페닐)-벤젠-1,2-디아민
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Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
화학 물질
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Methyl 5-Methoxy-2-nitro-4-(3-(pyrrolidin-1-yl)propoxy)benzoate
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Camptothecin and minor-groove binder hybrid molecules: Synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro
화학 물질
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1H-Pyrrole-2-carboxylicacid,4-amino-1-(methoxymethyl)-,ethylester(9CI)
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Synthesis and biological evaluation of orally active matrix metaloproteinase inhibitors
화학 물질
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(2R)-2-bromo-4-methylpentanoic acid t-butyl ester
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Development of prohibitin ligands against osteoporosis
화학 물질
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4-isopropylbenzenesulfonyl azide
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Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives
화학 물질
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N-(3,4-dichlorophenyl)-N'-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine
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Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition
화학 물질
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2-((4-chlorophenyl)disulfanyl)pyridine
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Thiophenol
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중탄산 나트륨
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Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid
화학 물질
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N-(3-((diethylamino)methyl)-2-ethoxybenzylidene)isonicotinohydrazide
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Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones
화학 물질
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5-[4-(3-ethyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
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Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
화학 물질
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7-methoxy-8-{6-[2-methoxy-4-[(E)-3-morpholino-3-oxo-1-propenyl]phenoxy]hexyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
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Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones
화학 물질
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2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl-
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Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers
화학 물질
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1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
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푸마르산
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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
화학 물질
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2-(4-{[(3-fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
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Synthesis, and antitumor activity of some N1-(Coumarin-7-yl) amidrazones and related congeners
화학 물질
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7-{2-[1-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one
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New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2
화학 물질
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C38H56O10Si
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Trisubstituted imidazoles as mycobacterium tuberculosis glutamine synthetase inhibitors
화학 물질
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2-ETHYNYL-6-METHOXYNAPHTHALENE 97
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Evaluation of aminohydantoins as a novel class of antimalarial agents
화학 물질
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3-cyclohexyl-2-imino-5,5-diphenylimidazolidin-4-one
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Substituted Aminoacetamides as Novel Leads for Malaria Treatment
화학 물질
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2-CHLORO-N-PYRAZIN-2-YLACETAMIDE
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Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
화학 물질
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2-methyl-5-benzylsulfonylamino-6-oxo-1 6-dihydro-1-pyrimidinylacetic acid
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(2-QUINOXALINON-3-YL)GLYOXAL DERIVATIVES FROM L-ASCORBIC ACID
화학 물질
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3-Methyl-benzoic acid [(2S,3S)-2,3,4-trihydroxy-1-(3-oxo-3,4-dihydro-quinoxalin-2-yl)-but-(Z)-ylidene]-hydrazide
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SOME 4-SUBSTITUTED 1-(3-PYRIDYLMETHYL)PIPERAZINES WITH ANTIHISTAMINE ACTIVITY
화학 물질
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[4-(4-methoxyphenyl)piperazin-1-yl](pyridin-3-yl)methanone
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Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N - trans -cinnamoyl derivatives of selected (un)modified aminoalkanols
화학 물질
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(2E)-N-(1-hydroxy-2-methylpropan-2-yl)-3-phenylprop-2-enamide
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Antiplasmodial metabolites isolated from the marine octocoral Muricea austera
화학 물질
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methyl-2',3',4'-tri-O-benzoyl-β-L-arabinopyranoside
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Synthesis and antitumor activity of lipid A analogs having a phosphonooxyethyl group with α- or β-configuration at position 1
화학 물질
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2-(diphenylphosphonooxy)ethyl 2-deoxy-6-O-<2-deoxy-4-O-diphenylphosphono-3-O-<(R)-3-tetradecanoyloxytetradecanoyl>-6-O-(2,2,2-trichloroethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyl>-3-O-tetradecanoyl-2-tetradecanoylamino...
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Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway
화학 물질
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2-(4-아미노페닐)-2-메틸프로판니트릴
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Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2- propen-1-amine derivatives
화학 물질
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Acetic acid 4-[(E)-1-(4'-bromo-biphenyl-4-yl)-3-dimethylamino-propenyl]-phenyl ester
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Identification of (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide as a novel potent and selective opioid κ receptor antagonist
화학 물질
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(3R)-4-(3-isopropoxyphenyl)-1,3,4-triMethylpiperidine
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Synthesis of novel pyrazole and dihydropyrazoles derivatives as potential anti-inflammatory and analgesic agents
화학 물질
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1-benzyl-4-methyl-3-[4-(methylsulfanyl)phenyl]-4,5-dihydro-1H-pyrazole
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Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel
화학 물질
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7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-13-O-{3-(tert-butoxycarbonylamino)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoropropionyl}-10-deacetylbaccatin III
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