생체 검사
작용 메커니즘에 대해 좀 더 알아보기 위해 이 화합물들이 DNA 위상 구조, DNA 절단, 단백질-DNA 상호작용에 미치는 영향을 실험을 통해 연구했습니다.이러한 분석은 잡화 화합물이 위상 이기종 효소 II 및 DNA와 효과적으로 결합하는지 확인하는 데 도움이 됩니다.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
생체 검사의 학술 논문
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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA
화학 물질
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
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Synthesis of iodo-aryl-azido adenosine analogs as affinity ligands for adenylyl cyclase
화학 물질
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(4-Amino-3-iodophenyl)acetic acid
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Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor
화학 물질
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1-methoxy-5-nitro-4-phenylisoquinoline
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Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design
화학 물질
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2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
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Optimization of the anti-cancer activity of the phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: Switching thiourea with 1,2,3-triazole
화학 물질
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(1-(5-chloro-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)(phenyl)methanone
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Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
화학 물질
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N-(2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl)methanesulfonamide
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Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
화학 물질
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6-{2-[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetylamino}hexanoic acid
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Exploration of SAR regarding glucose moiety in novel C-aryl glucoside inhibitors of SGLT2
화학 물질
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(2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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Design and synthesis of gramicidin s analogs with high antibiotic activity
화학 물질
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Boc-D-Lys(Cl-Z)-D-Leu-Pro-OMe
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Design, synthesis, and antitumor activity-absolute configuration relationships of podophyllotoxin aza-analogues
화학 물질
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2-aza-4'-demethyldeoxypodophyllotoxin
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Synthesis and evaluation of [14C]-labelled and fluorescent-tagged paclitaxel derivatives as new biological probes
화학 물질
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(2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
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Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds
화학 물질
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7-bromo-N-[(1-oxyl-4-bromo-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical
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Lead optimization of isocytosine-derived xanthine oxidase inhibitors
화학 물질
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C16H18N4O2
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Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations
화학 물질
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4-(4-{[(9H-fluoren-9-ylmethoxycarbonyl)prop-2-ynylamino]methyl}-3,5-dimethoxyphenoxy)butyric acid
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Synthesis and structure-activity relationship study of antidiabetic penta-O-galloyl-D-glucopyranose and its analogues
화학 물질
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1,2,3,4-tetrakis-O-(3,4,5-trihydroxybenzoyl)-alpha-D-glucopyranose
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CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives
화학 물질
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5-BROMO-2-[(4-클로로벤질)옥시]벤잘데하이드
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Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist
화학 물질
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1-(5-메틸-4-이속사졸릴)-1-에타논
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Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity
화학 물질
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methyl 3-(phenethylcarbamoyl)propylcarbamate
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The chemistry of 2',3'-seconucleosides II. Reactions and biological properties of 2',3'-secopyrimidine ribonucleosides
화학 물질
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2',3'-di-O-mesyl-5-methyl-5'-O-trityl-2',3'-secouridine
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Structure-activity correlations of cytochalasins. Novel halogenated and related cytochalasin C and D derivatives
화학 물질
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12-iodocytochalasin C
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1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl] -urea derivatives as small molecule heparanase inhibitors
화학 물질
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2-(4-Aminophenyl)-5,6-dimethyl benzimidazole
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Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors
화학 물질
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L-Proline, 1-(1,2-dioxo-3-phenylpropyl)-, phenylmethyl ester
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Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M
화학 물질
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1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone
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Parallel synthesis of DAPT derivatives and their γ-secretase- inhibitory activity
화학 물질
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글리신, N-[(3,5- 디 플루오로 페닐) 아세틸] -L- 알라 닐 -2- 페닐-, (2S)-
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Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands
화학 물질
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ethyl (2R,5R)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]-8,8-dimethyl-7,9-dioxatricyclo[4.3.0.02,4]nonane-2-carboxylate
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Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
화학 물질
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3-{[(1S)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
화학 물질
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ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
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De novo synthesis of modified saxitoxins for sodium ion channel study
화학 물질
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C24H28N6O8S2
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A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions
화학 물질
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2-MERCAPTO-6-THIEN-2-YL-4-(TRIFLUOROMETHYL)-PYRIDINE-3-CARBONITRILE
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Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications
화학 물질
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(2R,3S,4R,5R)-5-((benzoyloxy)methyl)-3-chlorotetrahydrofuran-2,4-diyl dibenzoate
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Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor
화학 물질
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1-(cyclohexylmethyl)-4-iodo-1H-pyrazole
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Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors
화학 물질
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ethyl 5-(4-(4-fluorobenzamido)phenyl)isoxazole-3-carboxylate
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HCl
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Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4
화학 물질
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ethyl 2-benzoyl-5-phenyl-1-(4-(phenylethynyl)phenyl)-1H-pyrrole-3-carboxylate
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Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors
화학 물질
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N-[4-(imidazo[1,2-b]pyridazin-6-yloxy)phenyl]-N'-phenylurea
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Synthesis Of Phosphonate Analogs of Lipid X
화학 물질
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C32H56ClO4P
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Synthesis of acyclic nucleotide analogues derived from 2-amino-6-C-substituted purines via cross-coupling reactions of 2-amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with diverse organometallic reagents
화학 물질
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2-Amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-phenylpurine
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Synthesis of the Vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs
화학 물질
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2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl 2,6-di{[(benzyloxy)carbonyl]amino}hexanoate
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α-tocopherol
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Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C′-diphenylcarborane scaffold as
ahydrophobic pharmacophore화학 물질
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1-(4-cyanophenyl)-2-(4-nitrophenyl)-1,2-dicarba-closo-dodecaborane
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Synthesis and modifications of a small library of 1,4-benzodiazepin-3-ones toward potential inhibitors of the collagen-von Willebrand Factor interaction
화학 물질
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(2-fluoro-5-nitrophenyl)-N-(4-methoxybenzyl)-methanamine
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Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors
화학 물질
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(4,4′,5,5′-tetrachloro-1′H-1,3′-bipyrrole-2,2′-diyl)bis((5-chloro-2-hydroxy-4-methylphenyl)methanone)
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테트라 히드로 푸란
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아세토 니트릴
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