약효단
분자 중 그 생물학적 활성을 담당하며 특정 표적과 결합하는 부분.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
약효단의 학술 논문
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Imidazo[1,2-a]pyridines that directly interact with hepatitis C NS4B: Initial preclinical characterization
화학 물질
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(3-chloro-6-furan-3-yl-8-trifluoromethyl-imidazo[1,2-a]pyridin-2-yl)-[3-(2-fluoro-phenyl)-pyrrolidin-1-yl]-methanone
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Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore
화학 물질
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2'-fluoro-4-nitro-biphenyl-2-carboxylic acid
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Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase
화학 물질
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Benzamide, N-[(diphenylamino)thioxomethyl]-4-nitro-
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Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore
화학 물질
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5-nitro-2-(2-phenylethyl)-1H-isoindole-1,3(2H)-dione
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Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors
화학 물질
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phenyl 3,4,6-tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside S-oxide
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Drug evolution concept in drug design: 1. Hybridization method
화학 물질
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2-diethylaminoethyl 4-amino-2-methoxybenzoate
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Modulation of breast cancer resistance protein (BCRP/ABCG2) by non-basic chalcone analogues
화학 물질
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(E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one
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Phenethyl ester derivative analogues of the C-terminal tetrapeptide of gastrin as potent gastrin antagonists
화학 물질
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(tert-butyloxycarbonyl)-L-leucyl-β-benzyl-L-aspartic acid phenethyl ester
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Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: Pharmacophore identification based on the screening hit closantel
화학 물질
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Phosphorane, [(3,4-dichlorophenyl)methylene]triphenyl-
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Ramberg-Backlund rearrangement vs. β-Elimination of haloform from trichloro and trifluoromethyl sulfones
화학 물질
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Diphenylmethyl-dichlormethyl-sulfon
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Synthesis and xanthine oxidase inhibitory activity of 4,6-disubstituted 1-p-chlorophenylpyrazolo[3,4-d]pyrimidines
화학 물질
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1-(4-chlorophenyl)-4,6-dimethoxy-1H-pyrazolo[3,4-d]pyrimidine
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Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid
화학 물질
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(2S,3R)-3-(3-(benzyloxy)-5-carboxyphenyl)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carboxylic acid
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DBU-Catalyzed Deconjugation of 7-Substituted 3,4-Didehydro-2-oxepanones. Deuterium Incorporation, Significance of the Imine Double Bond, and Application to the Synthesis of a Key Pharmacophore
화학 물질
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Cyclohexanecarboxylic acid, 2-oxo-1-(phenylmethyl)-, methyl ester
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1H-indole derivatives as calcium antagonists
화학 물질
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[3-(1-Hydroxy-propyl)-2-methyl-5-nitro-indol-1-yl]-phenyl-methanone
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Defining a minimum pharmacophore for simocyclinone D8 disruption of DNA gyrase binding to DNA
화학 물질
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3-amino-7-(benzyloxy)-2H-chromen-2-one
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Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design
화학 물질
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N-(4-(4-bromophenyl)-1-hydroxy-2-(hydroxymethyl)butan-2-yl)acetamide
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Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists
화학 물질
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(E)-N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide
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Synthesis, biological evaluation and molecular docking studies of novel quinazolinones as antitubercular and antimicrobial agents
화학 물질
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2-methylsulfanyl-3-(4-chlorophenyl)-3H-quinazolin-4-one
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Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore
화학 물질
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N-(2,6-다이메틸페닐)말레아믹산
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Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors
화학 물질
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5-(2,4-difluorophenyl)-2-furoyl chloride
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Structure-activity relationship studies on N′-aryl carbohydrazide P2X7 antagonists
화학 물질
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5-hydrazino-isoquinoline dihydrochloride
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Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors
화학 물질
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N6-<4-<<<4-<<<<2-<(Bromoacetyl)amino>ethyl>amino>carbonyl>methyl>anilino>carbonyl>methyl>phenyl>adenosine
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Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents
화학 물질
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2-[(3,4-Dimethyl-phenylamino)-methylene]-malononitrile
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Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptors
화학 물질
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N-(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-7-nitro-1H-benzimidazole-4-carboxamide
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Flavones. 3. Synthesis, biological activities, and conformational analysis of isoflavone derivatives and related compounds
화학 물질
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4H-1-Benzopyran-4-one, 7-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-3-phenyl-2-(phenylmethyl )-, hydrochloride
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Design, synthesis and biological characterization of novel inhibitors of CD38
화학 물질
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1-[(2-benzyloxyethoxy)methyl]-3-aminocarbonylpyridinium chloride
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Arylamidrazones as novel corticotropin releasing factor receptor antagonists
화학 물질
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C10H8BrF3N2O
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Nonsteroidal cardiotonics. 3. New 4,5-dihydro-6-(1H-indol-5-yl)pyridazine-3(2H)-ones and related compounds with positive inotropic activities
화학 물질
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2-Phenyl-5-(3-oxo-2,3,4,5-tetrahydro-6-pyridazinyl)-indole
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Identification of a new biaryl scaffold generating potent renin inhibitors
화학 물질
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1,3-dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene
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Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors
화학 물질
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Butanoic acid, 2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, methyl ester, (2S)-
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Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines
화학 물질
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[2-[4-(2-acetyl-phenyl)-piperazin-1-yl]-1-(4-chloro-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
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Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated
화학 물질
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4-((9H-carbazol-9-yl)methyl)-N-hydroxybenzamide
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Synthesis and cytotoxicity studies of 3,5-diaryl N-acetyl pyrazoline - Isatin hybrids
화학 물질
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1-(4,5-Dihydro-5-(4-hydroxy-3-methoxyphenyl)-3-(4-nitrophenyl)pyrazol-1-yl)ethanone
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Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors
화학 물질
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2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one
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Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid
화학 물질
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O-benzyl-N-(2-phenylethyl)hydroxylamine
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Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold
화학 물질
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5-[이소시아노-(톨루엔-4-술포닐)-메틸]-벤조[1,3]디옥솔
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Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors
화학 물질
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4-{2-[4-(propan-2-yloxy)phenoxy]ethyl}morpholine
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Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor
화학 물질
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tert-butyl 4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzylcarbamate
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Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication
화학 물질
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methyl 1-(4-fluorophenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide
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Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors
화학 물질
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methyl 4-oxo-4-(phenylamino)butanoate
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A novel class of nonpeptidic biaryl inhibitors of human cathepsin K
화학 물질
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1-(4-BROMO-PHENYL)-4-METHYL-PIPERAZINE
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Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy
화학 물질
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티에노[2,3-c]피리딘, 4,5,6,7-테트라하이드로-2-메틸-(9CI)
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4-Alkoxybenzamidines as new potent phospholipase A2 inhibitors
화학 물질
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Benzenecarboximidamide, 4-(octyloxy)-
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Synthesis and pharmacological evaluation of 5-dialkylaminomethyl-2-amino-2-oxazolines as H1-antagonists
화학 물질
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1-chloro-3-(4-benzylpiperidin-1-yl)propan-2-ol
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Non-thiol farnesyltransferase inhibitors: structure-activity relationships of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.
화학 물질
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N-[2-[3-benzoyl-4-[(4-methylphenyl)acetylamino]phenyl]]-Nγ-tert-butyloxycarbonyl-γ-aminobutyric acid amide
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