억제자
화학 반응이나 과정을 늦추거나 멈추는 물질입니다.
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억제자의 학술 논문
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Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus (1)
화학 물질
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2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
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SYNTHESIS OF A NOVEL HMG-COA REDUCTASE INHIBITOR
화학 물질
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Butanoic acid, 2-[bis(4-fluorophenyl)methylene]-3-methyl-, ethyl ester
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Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer
화학 물질
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2-(4-bromophenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
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Synthesis of Verrucarin B
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2-(p-Tolylsulfonyl)ethyl 5-<(tert-Butyldimethylsilyl)oxy>-3-methyl-2(S),3(R)-epoxypentanoate
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Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase
화학 물질
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tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate
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Lupinacidin C, an inhibitor of tumor cell invasion from micromonospora lupini
화학 물질
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(R/S)-3-methoxy-2-methyl-6-[(S)-3-methylpentyl]-2-cyclohexen-1-one
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Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease
화학 물질
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N-(6-(1H-indol-4-yl)-1H-indazol-4-yl)benzamide
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Synthesis of iminothiasugar as a potential transition-state analog inhibitor of glycosyltransfer reactions
화학 물질
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methyl 2,5-anhydro-3-O-benzyl-2,5-dideoxy-2-thio-β-D-arabino-pentofuranoside
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Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid
화학 물질
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acetamide, N-(4-tricyclo[3.3.1.1~3,7~]dec-1-ylphenyl)-
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DNA Cleavage by a Synthetic Mimic of the Calicheamicin-Esperamicin Class of Antibiotics
화학 물질
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(RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiyne-1,10-diol
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Synthesis of a nucleoside phosphoramidate prodrug inhibitor of HCV NS5B polymerase: Phenylboronate as a transient protecting group
화학 물질
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triethylammonium 2-(2,2-dimethyl-3-(trityloxy)propanoylthio)ethyl phosphonate
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Synthesis of 4-fluorinated UDP-MurNAc pentapeptide as an inhibitor of bacterial growth
화학 물질
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allyl 2-acetamido-2-deoxy-3-O-(4-methoxybenzyl)-6-O-benzyl-α-D-galactopyranoside
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Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L
화학 물질
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[[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone
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N-phosphonacetyl-L-isoasparagine a potent and specific inhibitor of Escherichia coli aspartate transcarbamoylase
화학 물질
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Boc-L-aspartic acid 4-benzyl ester
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Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor
화학 물질
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Benzenamine, 2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2 H-tetrazol-5-yl]-4,5-dimethoxy-
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Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4, 5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
화학 물질
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1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
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Discovery of
anew potent bisamide FMS kinase inhibitor화학 물질
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N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide
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Poststatin, a new inhibitor of prolyl endopeptidase. V. Endopeptidase inhibitory activity of poststatin analogues
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(S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-2-phenyl-acetylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester
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Novel sulfonamide derivatives as inhibitors of histone deacetylase
화학 물질
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Hexanoic acid, 6-[(phenylsulfonyl)amino]-, methyl ester
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Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition
화학 물질
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1-Naphthaleneacetonitrile, a-[[[3-(trifluoromethyl)phenyl]methyl]amino]-
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3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII
화학 물질
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2-amino-4-chloro-N-methoxybenzamide
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Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain
화학 물질
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2-benzyl-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde
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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
화학 물질
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tert-Butyl ((3R,5S)-rel-5-methylpiperidin-3-yl)carbamate
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Derivatives of 2-Methylenepenam: Analogues of Clavulanic Acid
화학 물질
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4-(triphenylmethylthio)azetidin-2-one
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Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor
화학 물질
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2-(methylsulfanyl)-1,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one
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Synthesis of (+)-1,5-dideoxy-1,5-imino-D-galactitol, a potent α-D-galactosidase inhibitor
화학 물질
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(2S,3S,4S)-1-(benzylamino)-2,3,4-tri-(benzyloxy)-5-hexene
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3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)
화학 물질
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2-chloro-5-(Boc-amino)benzyl mesylate
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Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)
화학 물질
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methyl 2-chloro-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate
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Orally active hydroxamic acid inhibitors of leukotriene biosynthesis
화학 물질
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N-[1-(4-Butoxy-phenyl)-ethyl]-hydroxylamine
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(1 S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio- d -glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment
화학 물질
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(5-bromo-2-chloro-4-methoxyphenyl)(4-ethylphenyl)methanone
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L-373,890, an anchiral, noncovalent, subnanomolar thrombin inhibitor
화학 물질
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tert-butyl 2-(6-methyl-2-oxo-3-(phenylmethylsulfonamido)pyridin-1(2H)-yl)acetate
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Selective inhibition of type II dehydroquinases
화학 물질
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3-deoxyquinic acid
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Design, synthesis, and biological activity of piperidine diamine derivatives as factor Xa inhibitor
화학 물질
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1H-Indole-2-carboxylic acid, 5-chloro-, 4-nitrophenyl ester
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Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation
화학 물질
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Benzene, 1,2,3-trimethoxy-5-(phenylmethoxy)-
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1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile
화학 물질
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5-((R)-2-Methoxy-2-phenylacetyl)-3-[4-(4-Methylpiperazin-1-yl)benzoylaMino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester
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Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor
화학 물질
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2(5H)-Furanone, 3-[4-(methylsulfonyl)phenyl]-4-phenyl-
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The first chemical synthesis of the core structure of the benzoylhydrazine-NAD adduct, a competitive inhibitor of the Mycobacterium tuberculosis enoyl reductase
화학 물질
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3H-Pyrrolo[3,4-c]pyridin-3-one, 1,2-dihydro-1-hydroxy-1-phenyl-
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Synthesis and kinetic analysis of the N-acetylhexosaminidase inhibitor XylNAc-isofagomine
화학 물질
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Benzyl 5-broMo-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate
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Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives
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(2E)-1-(5-bromo-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
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Synthesis of New Pyrrolo[2, 3-b]pyridines as a Potent Inhibitor of Tumour Necrosis Factor Alpha
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2-[2-(4-Bromophenyl)-2-Oxoethyl]Propanedinitrile
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Practical synthesis of a potent hepatitis C virus RNA replication inhibitor
화학 물질
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4-아미노-7H-피롤로[2,3-d]피리미딘-2-설핀산
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