생체 테스트에서
A. 가장 유망한 화합물을 선택하여 동물 모델(예: 설치류, 개 또는 비인간 영장류)에서 체내 실험을 실시합니다. 화합물이 AVP로 인한 혈관 수축의 능력을 차단하는 동시에 이들의 약대역학 및 독성도 평가한다.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
생체 테스트에서의 학술 논문
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Design of potent and selective antagonists of the vasopressor responses to arginine-vasopressin
화학 물질
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3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
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A study of anti-inflammatory and analgesic activity of new 2,4,6-trisubstituted pyrimidines
화학 물질
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3-bromo-4'-amino-chalcone
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Design, synthesis, and evaluation of novel anti-trypanosomal compounds
화학 물질
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N-(3-chlorobenzyl)-N-methylpiperidin-4-amine
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Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ2 receptors
화학 물질
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2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one
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New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
화학 물질
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6-[(4-Chloro-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one
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Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
화학 물질
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Methyl 5-Methoxy-2-nitro-4-(3-(pyrrolidin-1-yl)propoxy)benzoate
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CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives
화학 물질
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5-BROMO-2-[(4-클로로벤질)옥시]벤잘데하이드
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Development of prohibitin ligands against osteoporosis
화학 물질
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4-isopropylbenzenesulfonyl azide
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Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives
화학 물질
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N-(3,4-dichlorophenyl)-N'-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine
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Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid
화학 물질
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N-(3-((diethylamino)methyl)-2-ethoxybenzylidene)isonicotinohydrazide
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Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones
화학 물질
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5-[4-(3-ethyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
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Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators
화학 물질
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4-methylphenyl 3-[({7-[({7-[({3-[(4-methylphenyl)oxysulfonyl]phenyl}amino)sulfonyl]-2-naphthyl}amino)carbonylamino]-2-naphthyl}sulfonyl)amino]benzenesulfonate
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5-Amino-2-chlorobenzoic acid
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Triphosgene
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Synthesis, and antitumor activity of some N1-(Coumarin-7-yl) amidrazones and related congeners
화학 물질
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7-{2-[1-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one
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Evaluation of aminohydantoins as a novel class of antimalarial agents
화학 물질
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3-cyclohexyl-2-imino-5,5-diphenylimidazolidin-4-one
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Substituted Aminoacetamides as Novel Leads for Malaria Treatment
화학 물질
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2-CHLORO-N-PYRAZIN-2-YLACETAMIDE
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Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
화학 물질
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2-methyl-5-benzylsulfonylamino-6-oxo-1 6-dihydro-1-pyrimidinylacetic acid
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SOME 4-SUBSTITUTED 1-(3-PYRIDYLMETHYL)PIPERAZINES WITH ANTIHISTAMINE ACTIVITY
화학 물질
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[4-(4-methoxyphenyl)piperazin-1-yl](pyridin-3-yl)methanone
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Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel
화학 물질
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7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-13-O-{3-(tert-butoxycarbonylamino)-3-[(1-tert-butoxycarbonyl)pyrrole-2-yl]-2,2-difluoropropionyl}-10-deacetylbaccatin III
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Improved delivery through biological membranes VIII: Design, synthesis, and in vivo testing of true prodrugs of aspirin
화학 물질
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methylsulfonylmethyl benzoate
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HL 752: A potent and long-acting antispasmodic agent
화학 물질
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4-(2-PIPERIDYLETHOXY)BENZOPHENONE
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Synthesis, cleavage, and antifungal activity of a number of novel, water-soluble ester prodrugs of antifungal triazole CS-758
화학 물질
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Acetic acid, hydroxy-, (4-methoxyphenyl)methyl ester
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Synthesis and Pharmacological Evaluation of New Chemical Entities from Ibuprofen as Novel Analgesic Candidates
화학 물질
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에틸(S)-(-)-2-((메틸술포닐)옥시)-프로피오네이트, TECH., 90
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에틸 만델 레이트
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Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
화학 물질
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7-methoxy-8-{6-[2-methoxy-4-[(E)-3-morpholino-3-oxo-1-propenyl]phenoxy]hexyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
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Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones
화학 물질
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2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl-
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Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2
화학 물질
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methyl acetamido-2,6-anhydro-3,5-dideoxy-9-p-toluenesulfonyl-D-glycero-D-galactonon-2-enonate
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Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers
화학 물질
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1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone
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푸마르산
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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
화학 물질
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2-(4-{[(3-fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
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Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P'2-P'3 amide bond isostere
화학 물질
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(R)-(+)-2-(α-(i-부틸)MethanaMine)-1H-벤즈이미다졸, Min. 98% (R)-i-Bu-BIMAH
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ACETIC ACID
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Synthesis and biological evaluation of novel tamoxifen analogues
화학 물질
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N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)propionamide
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Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
화학 물질
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N1-(7-chloroquinolin-4-yl)-N2-{2-[(dimethylamino)methyl]benzyl}ethan-1,2-diamine
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