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하이패스 필터링(HTS)
HTS는 비교적 짧은 시간 내에 칼륨 통로를 차단하는 다량의 화합물의 능력을 테스트하는 것과 관련된다.자동화와 로봇 기술은 종종 이 과정을 가속화하는 데 이용된다.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
하이패스 필터링(HTS)의 학술 논문
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Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action
화학 물질
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1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate
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Discovery of a novel small molecule agonist scaffold for the APJ receptor
화학 물질
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(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid
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Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties
화학 물질
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methyl 3-(4-((2-chloropyridin-4-yl)ethynyl)phenyl)propanoate
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Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models
화학 물질
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4-(bromomethyl)-N-cyclohexyl-N-methylbenzenesulfonamide
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Identification of arginine analogues as antagonists and agonists for the melanocortin-4 receptor
화학 물질
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(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER
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Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2
화학 물질
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methyl 3-{N-(1-butyl)-2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzamido}benzoate
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2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazoles: Search for anticancer agents
화학 물질
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2-(2-fluorobiphenyl-4-yl)-6-phenylimidazo[2,1-b][1,3,4]thiadiazole
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Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling
화학 물질
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5-chloro-N4-methyl-N2-phenylpyrimidine-2,4-diamine
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Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists
화학 물질
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[4-(2-benzyloxy-4-fluoro-phenyl)-2,6-diisopropyl-5-vinyl-pyridin-3-yl]-methanol
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Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors
화학 물질
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(S)-tert-부틸 1-(3-a미노피리딘-4-일)피페리딘-3-일카르바메이트
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Rational discovery of a highly novel and selective mTOR inhibitor
화학 물질
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1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea
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Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2
화학 물질
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methyl acetamido-2,6-anhydro-3,5-dideoxy-9-p-toluenesulfonyl-D-glycero-D-galactonon-2-enonate
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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
화학 물질
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2-(4-{[(3-fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
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Identification of potent non-peptide somatostatin antagonists with sst3 selectivity
화학 물질
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2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-oxo-1,2-diphenyl-ethyl ester
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Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists
화학 물질
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[4-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-carbamic acid tert-butyl ester
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Promiscuity and selectivity in covalent enzyme inhibition: A systematic study of electrophilic fragments
화학 물질
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2-Propenamide, N-(4-fluorophenyl)-
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Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis
화학 물질
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N-(3-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide
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Synthesis and estrogen receptor affinity of 2,3-diarylindoles
화학 물질
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1H-Indol-5-ol, 2,3-diphenyl-
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Structure-activity relationships of arylbenzofuran H3 receptor antagonists
화학 물질
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4-(3-bromo-2-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}-1-benzofuran-5-yl)benzonitrile
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Double asymmetric iodoamination; synthesis of C2 symmetric and meso-amino alcohols
화학 물질
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((1S,2R,3S,4R)-1-Benzyl-4-tert-butoxycarbonylamino-2,3-dihydroxy-5-phenyl-pentyl)-carbamic acid tert-butyl ester
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Arylamidrazones as novel corticotropin releasing factor receptor antagonists
화학 물질
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C10H8BrF3N2O
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Identification of a new biaryl scaffold generating potent renin inhibitors
화학 물질
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1,3-dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene
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Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors
화학 물질
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Butanoic acid, 2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, methyl ester, (2S)-
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Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines
화학 물질
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[2-[4-(2-acetyl-phenyl)-piperazin-1-yl]-1-(4-chloro-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
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Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold
화학 물질
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5-[이소시아노-(톨루엔-4-술포닐)-메틸]-벤조[1,3]디옥솔
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Design, synthesis, and structure-activity relationships of novel bicyclic azole-amines as negative allosteric modulators of metabotropic glutamate receptor 5
화학 물질
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2-(2-phenyl-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)nicotinonitrile
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Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome β1 and β5 subunits
화학 물질
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(4-티엔-2-일테트라히드로피란-4-일)메틸아민
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Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box
화학 물질
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3-아미노-N-(4-메톡시-페닐)-벤젠술폰아미드
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Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication
화학 물질
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methyl 1-(4-fluorophenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide
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4-Alkoxybenzamidines as new potent phospholipase A2 inhibitors
화학 물질
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Benzenecarboximidamide, 4-(octyloxy)-
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Novel cAMP PDE III Inhibitors: 1,6-Naphthyridin-2(1H)-ones
화학 물질
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5-(4-aminophenyl)-1,6-naphthyridin-2(1H)-one
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PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development
화학 물질
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5-[[4-(2-oxo-2-phenylethoxy)phenyl]methyl]-2,4-thiazolidinedione
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Discovery of novel quinolinone adenosine A2B antagonists
화학 물질
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2-(1,3-thiazol-2-yl)acetonitrile
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New antiprotozoal agents: Their synthesis and biological evaluations
화학 물질
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N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide
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Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT
화학 물질
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4-(2-(5-(chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole
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Identification of novel mammalian squalene synthase inhibitors using a three-dimensional pharmacophore
화학 물질
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Acetic acid (3aS,4R,5S,6aR)-4-acetoxymethyl-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester
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