생물학 평가
일단 이 화합물들이 합성되면, 그들은 실제 생체 시스템에서 PRMT5를 억제하는 유효성을 평가하기 위해 생체 테스트에서 테스트됩니다.이 단계는 후보 약물로서의 이 화합물의 잠재력을 확인하는 데 필수적이다.
화학 원료를 구입해야하는 경우 요청 정보를 제출하여최신견적을받으십시오.
생물학 평가의 학술 논문
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Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations
화학 물질
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5-(3,4-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
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Discovery of simplified N2-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: Efficient synthetic approaches, biological evaluations and molecular docking studies
화학 물질
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6-Amino-2-phenethyl-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Stereospecific synthesis and biological evaluations of β-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine
화학 물질
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1-(2-O-acetyl-3,5-di-O-benzoyl-β-L-xylofuranosyl)-5-fluorouracil
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Syntheses and Biological Evaluations of 3'-Deoxy-3'-C-Branched-Chain-Substituted Nucleosides
화학 물질
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Thiocarbonic acid O-[(2R,3R,4R,5S)-5-benzyloxymethyl-4-fluoromethyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester
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Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations
화학 물질
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4'-클로로비페닐-3-카르발데하이드
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