N-(12-시아닌돌리지노[2,3-b]퀴녹살린-2-일)-2-티오펜카르복사미드

기본 정보

• 표준명: N-(12-시아닌돌리지노[2,3-b]퀴녹살린-2-일)-2-티오펜카르복사미드
• CAS 레지스트리 번호: 487020-03-1
• 분자식: C20H11N5OS
• 분자 무게: 369.406
• HS 코드: 2922500090
• Mol 파일: 487020-03-1.mol

동의어: N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxaMide;HI-TOPK-032;HI-TOPK-32

관련 CAS 번호: 40000-20-2 40000-79-1 40000-89-3 400010-39-1 400-01-1 4000-16-2 400018-92-0 400024-11-5 40002-62-8 400031-56-3

표준명의 화학적 성질

물리적 데이터:

안전정보:

• 픽토그램:
• 위험 코드:
• 진술:
• 안전 선언문:

사용:

• 소개 및 적용: N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide, also known as HI-TOPK-032, is a novel TOPK inhibitor that has been shown to effectively suppress the growth of colon cancer and glioma initiating cells both in vitro and in vivo. It works by blocking the phosphorylation of the substrate histone H2AX with an IC50 value of ~2 μM and providing complete inhibition at 5 μM. In addition, HI-TOPK-032 has been used as a PDZ binding-kinase (PBK) inhibitor and has been shown to inhibit checkpoint kinase 1 (Chk1; IC50 = 9.6 μM) and MEK1 (40% inhibition at 5 μM). However, it does not alter the activities of ERK1, JNK1, or p38 MAPK at 2 μM.