비신돌릴말레이미드 I 염산염

기본 정보

• 표준명: 비신돌릴말레이미드 I 염산염
• CAS 레지스트리 번호: 176504-36-2
• 분자식: C25H24N4O2.HCl
• 분자 무게: 0
• HS 코드: 2933998090
• Mol 파일: 176504-36-2.mol

동의어: 3-[1-(디메틸아미노프로필)인돌-3-일]-4-(인돌-3-일)말레이미드 염산염; 비신돌릴말레이미드 I(염산염); 비신돌릴말레이미드 I. 염산염 [GF-109203K;3-[1-[3-(디메틸아미노)프로필]-1H-인돌-3-일]-4-(1H-인돌-3-일)-1H-피롤-2,5-디온 일염산염;BIM 1염산염

관련 CAS 번호: 1000017-93-5 1000017-94-6 1000017-95-7 1000017-98-0 1000018-03-0 1000018-06-3 1000018-13-2 1000018-17-6 1000018-21-2 1000018-25-6

표준명의 화학적 성질

물리적 데이터:

안전정보:

• 픽토그램:
• 위험 코드:
• 진술:
• 안전 선언문:

사용:

• 소개 및 적용: GF 109203X hydrochloride, also known as Bisindolylmaleimide I (BIM I), is a highly selective and cell-permeable inhibitor of protein kinase C (PKC) with a Ki value of 14 nM. It is structurally similar to staurosporine, but shows higher selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I acts as a competitive inhibitor for the ATP binding site of PKC and also inhibits glycogen synthase kinase-3 (GSK-3) with an IC50 value of 360 nM in primary adipocyte lysates and 170 nM in GSK3β immunoprecipitates derived from rat epididymal adipocytes. In addition, BIM I prevents collagen-triggered adenosine and ATP secretion and inhibits collagen and α-thrombin-induced platelet aggregation. It also functions as an anti-inflammatory agent and competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.