2- 하이드 록시 펜탄 디온 산

기본 정보

• 표준명: 2- 하이드 록시 펜탄 디온 산
• CAS 레지스트리 번호: 40951-21-1
• 분자식: C5H8O5
• 분자 무게: 192.079
• Mol 파일: 40951-21-1.mol

동의어: 2-하이드록시글루타르산 이나트륨 염, 2-하이드록시글루타르산 이나트륨 염, 최대 10% 메탄올 함유 )-2-하이드록시펜탄디오익산 이나트륨염, 2-하이드록시글루타르산이나트륨, 2-HG(나트륨염)

관련 CAS 번호: 494-97-3 40740-39-4 480438-72-0 481638-68-0 42002-99-3 40136-95-6 477953-17-6 4626-00-0 400648-69-3 4794-81-4

표준명의 화학적 성질

물리적 데이터:

안전정보:

• 픽토그램:
• 위험 코드:
• 진술:
• 안전 선언문:

사용:

• 소개 및 적용: 2-Hydroxyglutaric acid (2-HG) is a potential inhibitor of enzymes such as glutamate carboxypeptidase. 2-HG is an α-hydroxy acid that is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes can lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid. 2-HG can also be produced from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. Since 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, it can competitively inhibit α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases. Therefore, 2-HG has the potential to affect various cellular processes by inhibiting these enzymes.