4- [5- (4- 카르 밤 이미도 일 페닐) -2- 푸릴] 벤젠 카르복시 미다 미드

기본 정보

• 표준명: 4- [5- (4- 카르 밤 이미도 일 페닐) -2- 푸릴] 벤젠 카르복시 미다 미드
• CAS 레지스트리 번호: 55368-40-6
• 분자식: C18H16N4O
• 분자 무게: 0
• Mol 파일: 55368-40-6.mol

동의어: WR-199385;FuraMidine Dihydrochloride;4-[5-(4-carbamimidoylphenyl)-2-furyl]benzenecarboximidamide;2,5-Furandiylbis(1,4-phenylene)bisformamidine;DB75;DB-75;Furamidine

관련 CAS 번호: 55513-32-1 5435-42-7 58256-10-3 57543-72-3 59489-40-6 536975-50-5 54767-36-1 50562-22-6 58599-62-5 51568-06-0

표준명의 화학적 성질

물리적 데이터:

안전정보:

• 픽토그램:
• 위험 코드:
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• 안전 선언문:

사용:

• 소개 및 적용: Following the information provided, the synthesis and use of 4-[5-(4-carboethoxymethyl)-2-furanyl]-N,N-dimethylaniline (Furamidine), a diphenylfuran compound with antimicrobial, antiparasitic, and antitumor activities, can be summarized as follows: Furamidine is an analog of the aromatic drug pentamidine and a substrate of the organic cation transporter 1 (OCT1). It is a selective and cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 9.4 μM, and is more selective for PRMT1 than PRMT5, PRMT6, and PRMT4 (CARM1) with IC50 values of 166 μM, 283 μM, and >400 μM, respectively. Additionally, Furamidine is a potent, reversible, and competitive inhibitor of tyrosyl DNA phosphodiesterase 1 (TDP-1). Furamidine and its analogs have been found to exhibit antitumor activities and have shown antiproliferative activities against various tumor cell lines. A number of prodrugs of Furamidine dihydrochloride are currently being synthesized and are in clinical trial stages.