시클로 피아 존산

기본 정보

• 표준명: 시클로 피아 존산
• CAS 레지스트리 번호: 18172-33-3
• 분자식: C20H20N2O3
• 분자 무게: 336.39
• HS 코드: 29337900
• Mol 파일: 18172-33-3.mol

동의어: (6a-alpha,11a,11b-alpha)–10-acetyl-7-dimethyl-11-hydroxy-;9h-pyrrolo(1’,2’:2,3)isoindolo(4,5,6-cd)indol-9-one,2,6,6a,7,11a,11b-hexahydro;(6AA, 10Z, 11AB, 11BA)-6A,7,11A,11B-TETRAHYDRO-10-(1-HYDROXYETHYLIDENE)-7,7- DIMETHYL-6H-PYRROLO [1′,2′:2,3]ISOINDOLO [4,5,6-CD]INDOLE-9,11 (2H,10H)-DIONE;(6AR,11AS,11BR)-REL-10-ACETYL-2,6,6A,7,11A,11B-HEXAHYDRO-7,7-DIMETHYL-9H-PYRROLO[1′,2′:2,3]ISOINDOLO[4,5,6-CD]INDOL-9-ONE;ALPHA CYCLOPIAZONIC ACID;CPA;CYCLOPIAZONIC ACID;CYCLOPIAZONIC ACID, PENICILLIUM CYCLOPIUM

관련 CAS 번호: 1261615-96-6 1289387-63-8 111011-00-8 19688-04-1 1245647-59-9 1020253-02-4 115722-26-4 125812-04-6 129526-60-9 101420-81-9

표준명의 화학적 성질

물리적 데이터:

안전정보:

• 진술: 25

사용:

• 소개 및 적용: Cyclopiazonic acid (CPA) is a mycotoxin produced by various Aspergillus and Penicillium species. It is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, which alters calcium homeostasis and ATP-dependent calcium transport, resulting in the release of intracellular stored Ca2+ without increasing IP3. CPA has been used in various applications, such as an anti-arrhythmic agent in Langendorff-perfused murine hearts, a decrease in hormone-sensitive lipase activity and triacylglycerol hydrolysis in rat soleus muscle, and an inhibitor of endoplasmic reticulum Ca2+-ATPase. It has also been used as a standard in aflatoxin detection and quantification, a component in Ca2+-free DMEM/10% fetal bovine serum, a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in ER-to-Golgi trafficking, and an endoplasmic reticulum Ca2+-ATPase blocker to treat neurons and study the role of the ER in releasing and sustaining Ca2+ during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA. In vivo, CPA can induce ptosis, hypothermia, tremor, and cachexia, as well as lethality in rats, and tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.