너트린-3

기본 정보

• 표준명: 너트린-3
• CAS 레지스트리 번호: 548472-68-0
• 분자식: C30H30Cl2N4O4
• 분자 무게: 581.499
• Mol 파일: 548472-68-0.mol

동의어: (+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE;NUTLIN-3;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one;Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one;Nutlin-3, >=98%;NUTLIN-3 (Free base)

관련 CAS 번호: 55377-26-9 56030-49-0 5180-76-7 58-57-1 55150-67-9 56030-19-4 5932-27-4 51640-97-2 56904-15-5 5064-46-0

표준명의 화학적 성질

물리적 데이터:

안전정보:

• 픽토그램: Xi
• 위험 코드: Xi
• 진술: 36/37/38
• 안전 선언문: S26; S36

사용:

• 소개 및 적용: (±)-Nutlin-3은 p53-Mdm2 단백질-단백질 상호작용 억제제인 작은 분자 MDM2 항쌍으로, (+)-nutlin-3과其二项混合物입니다. In vivo에서 (±)-nutlin-3 (200 mg/kg twice daily)는 SJSA-1 오스테오사르코마 мышце xenograft 모델에서 튬 объем을 줄입니다.