테트라하이드로리딘

기본 정보

• 표준명: 테트라하이드로리딘
• CAS 레지스트리 번호: 18771-50-1
• 분자식: C9H16N2O6
• 분자 무게: 248.236
• Mol 파일: 18771-50-1.mol

동의어: 3,4,5,6-tetrahydrouridine;nsc-112907;nsc-112907-d;tetrahydro-4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyrimidinon;TETRAHYDROURIDINE;(4S)-3,4,5,6-Tetrahydro-4β-hydroxy-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one;3,4,5,6-Tetrahydrouridine (>80% by HPLC)

관련 CAS 번호: 13401-85-9 148-97-0 1485-92-3 15933-07-0 19007-32-0 179115-42-5 1196153-79-3 15183-81-0 121749-77-7 107549-24-6

표준명의 화학적 성질

물리적 데이터:

안전정보:

• 픽토그램:
• 위험 코드:
• 진술:
• 안전 선언문:

사용:

• 소개 및 적용: Tetrahydrouridine (THU) is a derivative of Uridine and a potent inhibitor of cytidine, which can be used as a potential treatment for tumors with highly expressed CDA. It inhibits cell proliferation through cell cycle regulation regardless of CDA expression levels. THU is a competitive, reversible inhibitor of cytidine deaminase with Ki values of 54 and 240 nM for human and E. coli enzymes, respectively. It is being evaluated in animal models and clinical trials, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, for the treatment of diseases such as cancer and mitochondrial DNA depletion syndrome.